Nestled in the lower part of the town, in an area likely named Gianguarna, a term of Arab origin, stands the quaint Church of the Annunziata. Originally dedicated to Saint Mary of the Sick, this church has preserved its ancient architectural essence, particularly in its 16th-century pronaos. A grand pointed arch marks the entrance, elevating the church's facade. To the right, two additional pointed arches rest on columns topped with cushions, all adorned with symbolic sculptures. A square bell gable, a recent addition, complements the old structure. Adjacent to the church was the Benedictine monastery, erected in the 15th century by Count Abatellis. Despite succumbing to a landslide at the end of the 18th century, which demolished the monastery, the church miraculously remained unscathed.

The church's interior, consisting of a single nave, is adorned with exquisite eighteenth-century stuccoes in pure gold. On the inner facade wall, remnants of an ancient fresco, now barely discernible, possibly depict the Coronation of the Virgin. Among its treasured artifacts is a large canvas portraying the Penitent Magdalene, attributed to the school of Guido Reni, salvaged from the similarly named, now-ruined church. Another eighteenth-century canvas captures the Annunciation of the Virgin, alongside artistic wooden statues, including the Madonna Annunziata and Saint James the Apostle, originally housed in his namesake church. The most venerated relic for the people of Cammarata is the Crucifix, known as "della Pioggia," associated with a miraculous tale preserved by tradition and chronicled by Domenico Di Marco.