During the fourteenth century the town of Cammarata developed "up to Porta Guagliarda"  where, as the name implies, one of the gates of the town stood. The aedicule of the Madonna della Porta also testifies to this, according to the widespread custom - as evidenced by many monuments in ancient cities - of placing the image of the Virgin, "Ianua coeli", near the most important doors, for protection and defense.

The natural line of the town's fortifications and, probably, at least in certain sections, of the walls, descended from there towards the south, along the natural valley - a real torrent, in winter - which reached the Cozzo della Vucciria and then ended with the another door which was located between San Domenico and San Biagio. In ancient documents, up to the beginning of the century. XVII, we speak of the district of Porta Guagliarda "or lo lavinaro" ».

"The district of San Vito probably arose later, between the fourteenth and fifteenth centuries, because at the beginning of the sixteenth century it is remembered as existing and equipped with a church".  The ancient church of S. Vito, prior to the 16th century, was small and had six altars. The current one - due to the style and the information found in some documents - can be considered built between the second half of the 16th century and the first of the 17th century. The church has a basilica plan with five pillars on each side and a chapel between the two apse chapels. It preserves notable works such as the ancient organ (of the '700), the artistic choir, the wooden Crucifix (of the' 600), the statues of S. Vito (of the '600), of S. Pietro, of S. Paolo, the broad bricks of the Holy Virgin and God the Father and the paintings of S. Placido, S. Eligio and S. Liborio. In the sacristy there is a carved wooden wardrobe decorated with cherubs and friezes, surmounted by a small shrine with the statuette of S. Vito.

An indication of the commercial importance of Cammarata, which due to the strong increase had taken on the appearance of a town, was the establishment of a hospital  (The hospital, near the church of S. Antonio (today S. Domenico), had existed since the 14th century. "Since the building had collapsed," the hospital was refounded by the priests of Cammarata on 6 January 1493 ". at the beginning of the 19th century, due to the unsafe building, the sick were transported to the monastery of the Annunziata, first, and then to a building located in front of the matrix. In 1937, following the testamentary bequests of the brothers Luigi and Salvatore Longo, the hospital was moved to the premises of via L. Longo and in 1984, for hygienic-sanitary reasons, in a new building in the district of S. Lucia.), the existence of a Jewish community and the construction of the churches of S. Domenico ("The church of S. Domenico was built by the Dominicans in place of the one dedicated to S. Antonio which had been granted to them in -1509, with the hospice, for use as a convent".  In 1913 a fire destroyed the apse and the roof. The reconstruction, begun in 1929, was completed in 1934. The church preserves the broad bricks of S. Giacinto, S. Vincenzo, S. Domenico, del Rosario, S. Agostino, Madonna del Ro), Santa Domenica  (The church of Santa Domenica had to be built towards the middle of the 15th century, because in a document it is mentioned as "Ecclesia di S. Domenica in dicta terra in which est confratria." The church, after the suppression of ecclesiastical property in 1866 , was deprived of the convent which was transformed into a town hall. It houses the statues of Mary Help of Christians, of St. Philip of Agira, of the Immaculate Conception (18th century) and the paintings of the Adoration of the Magi and of St. Cajetan . In the Altar of the Crucifix there is a silver tabernacle and a frontal in silver foil.) And of S. Giacomo and S. Giovanni Evangelista (This church, according to tradition, stands on an ancient Arab mosque; what is probable because St. James was considered the protector of Christians against the Moors. But the current church is not the old one - which however - it had to be close to it - because in 1576 it was already destroyed. " he rebuilt the church of S. Giovanni Evangelista, the confreres of S. Giaco mo asked and obtained from the Bishop to transfer their brotherhood to it. The church remained open for worship until the Second World War.).

"Only in 1312", - writes Msgr. De Gregorio «by a decree of Frederick II of Sicily, they were required to live in the ghetto which then became the commercial district. With this decree of 23 July the king prescribed that the Jews gather in a secluded place and outside the city walls and therefore, probably since then, they gathered in Cammarata in the area below S. Maria, in the land between the garden of S. Agostino and S. Vito, which, even today, is still sometimes called the quarter of the Jews. Their synagogue and also their cemetery were to be built there. With the affirmation of the Spaniards, tolerance towards the Jews diminished until Ferdinand the Catholic, on March 31, 1492, signed the decree for the expulsion of the Jews from all his domains ». (7) At the end of the fifteenth century Cammarata, due to the massive immigration of "new inhabitants", had seen the population increase considerably. In fact the inhabitants, which according to V. Amico towards the middle of the 16th century were 8,092, had exceeded the number of 7,000.